Product Description
Kryxana is an anti-cancer medicine that contains the active substance ribociclib. It is used for the treatment of metastatic breast cancer (cancer that has been spread to other body parts from breasts). It belongs to a group of medicines called cyclin-dependent kinase (CDK) inhibitors, works by blocking proteins (kinases) which are important for the growth and division of cells. This slows the growth of cancer cells and eventually kills them.
However, the uses of the medicine mentioned are not exhaustive; there may be other reasons or situations in which the medicine might be used.
Inform the doctor if you had pulmonary toxicity, renal dysfunction, diabetes, heart/heart rhythm disorders, low levels of electrolytes, liver problems, fever, sore throat, mouth ulcers due to infections.
Inform the doctor about all your medical conditions, prescription and non-prescription drugs, vitamin supplements, herbal medications, since Kryxana can interact with them. Kryxana can cause an allergic reaction in some patients therefore it is necessary to read the complete composition list and consult the doctor in case of any ingredient that induces allergies.
Consult the doctor if you are planning, on a pregnancy or breastfeeding.
It is advisable to avoid driving and operating heavy machinery during the course of Kryxana.
Indications of KRYXANA Tablet
Kryxana indicated for the treatment of patients with HER2-positive breast cancer that is advanced or has spread to other parts of the body.
Therapeutic Effects of KRYXANA Tablet
Kryxana Tablet contains Ribociclib, which is a CDK (cyclin-dependent kinase) inhibitor.
It works by blocking cyclin-dependent kinase 4 and 6 proteins, which are necessary for the growth and division of the cells. Thereby, slows down the growth of cancer cells and delays the progression of cancer.
Directions for Use
Kryxana Tablet should be taken with food preferably at the same time each day.
The Tablet should be swallowed whole with water and should not be crushed, chewed, or opened. The dosage and duration of treatment will depend on the individual’s condition and response to the medication and should be determined by the doctor.
Your doctor will decide the dose and frequency of administration based on your health condition.
A trained healthcare doctor will administer Kryxana. So, do not self-administer.
Storage
Kryxana Tablet should be stored below 30°C temperature at room temperature. Do no freeze.
If you are traveling, carefully follow all patient instructions for storing your medicine during travel. Avoid extreme heat or cold.
Keep in the original container to protect from light and moisture.
Keep Kryxana Tablet out of sight and reach of children.
Common:
- Nausea
- Vomiting
- Shortness of breath
- Sore mouth
- Loss of appetite
- Diarrhea
- Abdominal pain
- Rash
- Hair loss
- Headache & dizziness
- Risk of infections
Serious:
- Electrolyte imbalances
- Dehydration
- Kidney problems
- Liver damage
- Pneumonitis
- Difficulty in breathing
- Chest pain
Tell a doctor or nurse straight away, if you notice any of the side effects above.
Contraindications
Kryxana Tablet is contraindicated in patients with a known hypersensitivity to Kryxana or any of the excipients.
Drug Interactions
Kryxana might interact with other medicines. Therefore, it is recommended to inform your doctor about all the prescriptions you have.
Safety Advices for KRYXANA Tablet
Consult Your Doctor
Avoid alcohol consumption while taking Kryxana as it might cause increased dizziness and worsen any liver-related side effect. Consult your doctor if you have history of Alcohol intake.
UNSAFE
Kryxana Tablet is not recommended for use in pregnancy as it may harm your fetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before taking Kryxana Tablet. Using effective birth control methods while on treatment is suggested.
UNSAFE
Avoid breastfeeding your baby while on the treatment with Kadcyla, as it may pass through breast milk. Consult your doctor if you are breastfeeding before taking this medication.
UNSAFE
Kryxana may cause dizziness, tiredness, or spinning sensation in some patients. Therefore, avoid driving or operating machines that require mental concentration until you are not alert.
CONSULT YOUR DOCTOR
If you have a pre-existing or a history of lungs problems, consult your doctor before taking this medicine. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.
CONSULT YOUR DOCTOR
If you have a pre-existing or a history of liver problems, consult your doctor before taking this medicine. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.
CONSULT YOUR DOCTOR
If you have a pre-existing or a history of kidney disease, inform your doctor. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.
UNSAFE
Kryxana is not recommended for use in children as the safety and efficacy are not established.
- 1. Novartis Pharmaceuticals UK Ltd, Electronic medicines compendium (emc), [Revised on 18 Jan 2023], [Accessed on 29th March 2023], https://www.medicines.org.uk/emc/product/8110/smpc
- 2. Novartis Pharmaceuticals, U. S National Library of Medicine, [ Revised on Dec 2022] [Accessed on 28th March 2023], https://clinicaltrials.gov/ct2/show/NCT03701334
- 3. Novartis Pharmaceuticals Corporation, U.S. Food and Drug Administration. Highlights of Prescribing Information: Ribociclib. [Last revised 2017], [Accessed on 29th March 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209092s000lbl.pdf
- 4. Vincent T. DeVita Jr., Theodore S. Lawrence, Steven A. Rosenberg, Cancer Chemotherapy: Principles and Practice Authors, 10th Edition, 2020, 993-994
- 5. Ribociclib. East Hanover, New Jersey: Novartis Pharmaceuticals Corporation; 2007 [revised Mar. 2017]. [Accessed 27 Mar. 2019] (online) Available from
- 6. Ribociclib succinate. Surrey, UK: Novartis Pharmaceuticals UK Ltd.; 2019. [Accessed 22 Jan. 2019] (online) Available from

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