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Product Description
MEQSEL is an anti-cancer medicine that contains the active substance Trametinib. It is used alone or in combination with other medicines to treat skin cancer called melanoma and cancers with specific genetic mutations. It is also used along with dabrafenib in treating anaplastic thyroid cancer, non-small cell lung cancer, and unresectable or metastatic solid tumors with BRAF V600E mutation.
It belongs to the class of medicines known as kinase inhibitors. It works by blocking a specific enzyme called tyrosine kinase, which helps stop the abnormal growth of cancer cells.
Inform the doctor if you have any infection, bleeding disorders, calcium deficiency, high blood pressure, heart diseases, kidney diseases, liver diseases, seizures or vision problems.
Inform the doctor about all your medical conditions, prescription and non-prescription drugs, vitamin supplements, herbal medications, since MEQSEL can interact with them. MEQSEL can cause an allergic reaction in some patients therefore it is necessary to read the complete composition list and consult the doctor in case of any ingredient that induces allergies.
Consult the doctor if you are planning, on a pregnancy or breastfeeding.
It is advisable to avoid driving and operating heavy machinery during the course of MEQSEL.
Indications of MEQSEL
MEQSEL is indicated to be used alone or in combination with other medicines to treat skin cancer called melanoma and other cancers that have certain genetic mutations. It is also used along with dabrafenib in treating anaplastic thyroid cancer, non-small cell lung cancer, and unresectable or metastatic solid tumors with BRAF V600E mutation.
Therapeutic Effects of MEQSEL
MEQSEL contains Trametinib, a kinase inhibitor is an anti-cancer medication. It works by inhibiting Mitogen-activated extracellular signal-regulated kinase (MEK), which is a key protein in the Mitogen-activated protein kinase (MAPK) pathway. By doing so, it helps to block signals that promote the growth and division of cancer cells. This can slow down or stop the growth of malignant melanoma tumors.
Directions for Use
MEQSEL tablet should be swallowed whole with water and should not be crushed, chewed, or opened. The medicine can be taken with or without food. Taking these medicines regularly at the same time increases their effectiveness. A dose of this medicine should not be missed as it can affect your recovery. Take a missed dose as soon as possible, but skip it if the next dose is near; continue with your regular schedule. This medication may be used in combination with other medications. The dosage and duration of treatment will depend on the individual’s condition and response to the medication.
Your doctor will decide the dose and frequency of administration based on your health condition. Avoid self-medicating.
Storage
- MEQSEL tablet be stored in refrigerator at 2°C to 8°C. Do not freeze.
- If you are traveling, carefully follow all patient instructions for storing your medicine during travel. Avoid extreme heat or cold.
- Keep the injection in the original container to protect from light and moisture.
- Keep MEQSEL tablet out of sight and reach of children.
Common:
- Increased Thirst
- Swelling in the hands or feet
- Headache
- Fever
- Nausea & Vomiting
- Coughing and Sneezing
- Diarrhoea
- Fatigue
- Skin rash
- Acne
- Dry skin
- High blood pressure
- Eye problems, such as blurred vision or sensitivity to light
Serious:
- Severe skin reaction
- Bleeding problems
- Heart failure
- Irregular heartbeat
- Shortness of breath
- Liver injury or hepatitis
- Retinal detachment
- Gastrointestinal perforation
Contraindications
Meqsel is contraindicated in patients with a known hypersensitivity to Meqsel or any of the excipients.
Safety Advices for MEQSEL
Consult Your Doctor
It is unknown whether MEQSEL interacts with alcohol. It is best to avoid alcohol or limit your alcohol intake while taking any medication.
Unsafe
MEQSEL is not recommended for use in pregnant women. Hence, if you are pregnant or planning pregnancy, inform your doctor before taking MEQSEL. Your doctor will weigh the benefits and any potential risks before prescribing it to you.
Unsafe
Avoid breastfeeding your baby while on the treatment with MEQSEL, as it may pass through breast milk. Consult your doctor if you are breastfeeding before taking this medication.
Unsafe
MEQSEL may cause fatigue, dizziness, or blurred vision in some patients. Therefore, avoid driving or operating heavy machines that require mental concentration.
Caution
If you have any lung-related symptoms, consult your doctor before taking MEQSEL. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.
Caution
If you have a pre-existing or a history of liver problems, consult your doctor before taking MEQSEL. MEQSEL should be used cautiously in patients with hepatic impairment. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.
Caution
If you have a pre-existing or a history of kidney disease, inform your doctor. MEQSEL should be used cautiously in patients with moderate to severe renal impairment. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.
Unsafe
MEQSEL is not recommended for use in children below 18 years as the safety and efficacy are not established.
- 1. Novartis Pharmaceuticals Corporation, US Food and Drug Administration, [Revised on April 2018] [ Accessed on 28th March 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/204114s007lbl.pdf
- 2. Novartis Europharm Limited, Electronic medicines compendium (emc),[ Revised on Nov 2022] [Accessed on 28th March 2023], https://www.medicines.org.uk/emc/product/5072/smpc
- 3. Katzung and Trevor, Basic and Clinical Pharmacology, 14th Edition, 2018, 579
- 4. Goodman & Gilman's The Pharmacological Basis of Therapeutics, 13th Edition, 2018, 1625-1626
- 5. Novartis Pharmaceuticals Corporation; 2023. [Accessed 23 Nov. 2023] (online)
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