- Your cart is empty
- Continue Shopping
Product Description
Perjeta 420mg Injection is an anticancer medication containing the active constituent Pertuzumab. It is used to treat HER2-positive breast cancer in combination with other chemotherapy medications. It works by inhibiting the excess production of a human epidermal growth factor receptor 2 (HER2) protein in the mammalian cells. This causes inhibition of the cancer cell growth and, finally, initiation of apoptosis.
Inform the doctor about if you had Pulmonary toxicity, Renal dysfunction, Thrombocytopenia.
Inform the doctor about all your medical conditions, prescription and non-prescription drugs, vitamin supplements, herbal medications, since Perjeta 420mg can interact with them. Perjeta 420mg can cause an allergic reaction in some patients therefore it is necessary to read the complete composition list and consult the doctor in case of any ingredient that induces allergies.
Consult the doctor if you are planning, on a pregnancy or breastfeeding.
It is advisable to avoid driving and operating heavy machinery during the course of Perjeta 420mg.
Indications of PERJETA Injection
Perjeta 420mg indicated for the treatment of patients with HER2-positive breast cancer in combination with other chemotherapy medications.
Therapeutic Effects of PERJETA Injection
Perjeta 420mg Injection contains Pertuzumab, which belongs to the class of monoclonal antibodies. It works by inhibiting the excess production of a human epidermal growth factor receptor 2 (HER2) protein in the mammalian cells. This causes inhibition of the cancer cell growth and, finally, initiation of apoptosis.
Directions for Use
Perjeta is usually given as an intravenous injection once every 3 weeks. This medication may be used in combination with other chemotherapy medications.
The dosage and duration of treatment will depend on the individual’s condition and response to the medication and should be determined by the doctor.
Your doctor will decide the dose and frequency of administration based on your health condition.
A trained healthcare doctor will administer Perjeta 420mg. So, do not self-administer.
Storage
Perjeta 420mg Injection should be stored in refrigerator at 2°C to 8°C. Do not freeze.
If you are traveling, carefully follow all patient instructions for storing your medicine during travel. Avoid extreme heat or cold.
Keep in the original container to protect from light and moisture.
Keep Perjeta Injection out of sight and reach of children.
Common:
- Constipation
- Hair Loss
- Rash
- Sore Mouth
- Poor appetite
- Changes in taste
- Sleeping troubles
- Nose bleeds
- Heartburn
- Nail problems
- Producing more tears
- Feeling dizzy
- Dry and itchy skin
- Ear, nose, or throat infection
Serious:
- Severe or persistent diarrhea
- Low white blood cell count
- Infusion reactions with symptoms that can either be mild or more severe and may include feeling sick (nausea), fever, chills, feeling tired, headache, loss of appetite, joint and muscle pains, and hot flushes.
- Allergic and anaphylactic (more severe allergic) reactions with symptoms that may include swelling of your face and throat, with difficulty in breathing.
- Heart problems (heart failure) with symptoms that can include cough, shortness of breath, and swelling (fluid retention) in your legs or arms.
- Tumour lysis syndrome (a condition which may happen when cancer cells die quickly, causing changes in blood levels of minerals and metabolites shown in a blood test). Symptoms may include kidney problems (weakness, shortness of breath, fatigue and confusion), heart problems (fluttering of the heart at a faster or slower heartbeat), seizures, vomiting or diarrhoea and tingling in the mouth, hands or feet
Tell a doctor or nurse straight away, if you notice any of the side effects above.
Contraindications
Perjeta 420mg Injection is contraindicated in patients with a known hypersensitivity to Perjeta 420mg or any of the excipients.
Drug Interactions
Drug-Drug Interactions: Perjeta 420mg Injection may interact with anti-cancer drugs (anastrozole, carmustine, daunorubicin), monoclonal antibodies (abciximab, adalimumab), antibiotics (bleomycin), local anaesthetics (bupivacaine, butacaine).
Drug-Food Interactions: Avoid alcohol consumption and smoking.
Drug-Disease Interactions: Tell your doctor if you have heart problems like heart failure, irregular heartbeats, and uncontrolled high blood pressure, liver or kidney disease, lung disease problems.
Safety Advices for PERJETA Injection
Consult Your Doctor
It is unknown whether Perjeta 420mg Injection interacts with alcohol. Consult your doctor.
Unsafe
Perjeta 420mg Injection is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before taking Perjeta 420mg Injection. You should not become pregnant while you are taking Perjeta 420mg Injection for at least one week after your last dose of treatment. Using effective birth control methods while on treatment is suggested.
Unsafe
It is not known whether Perjeta passes into breast milk. Consult your doctor if you are breastfeeding before taking this medication.
Unsafe
Perjeta may cause dizziness, lightheadedness, or fainting in some patients. Therefore, avoid driving or operating machines that require mental concentration until you are not alert.
Caution
Limited data are available on the effect of Perjeta in hepatic-impaired patients. If you have a pre-existing or a history of liver problems, consult your doctor before taking this medicine. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.
Caution
Limited data are available on the effect of Perjeta in kidney-impaired patients. Hence, if you have a pre-existing or a history of kidney disease, inform your doctor. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.
Unsafe
Perjeta is not recommended for use in children as the safety and efficacy are not established.
FAQs
Ans – Perjeta is an intravenous injection used in the treatment of breast cancer.
Ans -Perjeta is consider cancer therapy and different from chemotherapy. Chemotherapy works by killing fast-growing cancer cells, but it also affects normal cells. Perjeta attacks certain proteins in breast cancer cells that cause rapid growth.
Ans - Avoid drinking alcohol during the treatment with Perjeta even though no interactions of both are known.
Ans - It is advisable to avoid driving and operating heavy machinery as Perjeta causes dizziness as one of the side effects.
Ans – Perjeta can cause harm to the fetus hence, it is advisable to avoid the pregnancy or consult the doctor for the same.
- 1. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 1095.
- 2. 2. Pertuzumab [FDA Label]. South San Francisco, CA: Genentech, Inc.; 2012. [Accessed 05 Feb. 2020] (online) Available from [https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/125409lbl.pdf]
Disclaimer
While we strive to provide complete, accurate, and expert-reviewed content on our ‘Platform’, we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user’s risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship. All Trademarks, Brands and Service marks that appear on this website belong to their respective owner.
