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Product Description
Phesgo is an injectable fixed-dose combination regimen containing pertuzumab and trastuzumab. It is used to treat HER2-positive breast cancer by inhibiting the excess production of a human epidermal growth factor receptor 2 (HER2) protein in the mammalian cells. This causes inhibition of the cancer cell growth and, finally, initiation of apoptosis.
Inform the doctor about if you had Pulmonary toxicity, Renal dysfunction, Thrombocytopenia.
Inform the doctor about all your medical conditions, prescription and non-prescription drugs, vitamin supplements, herbal medications, since Phesgo can interact with them. Phesgo can cause an allergic reaction in some patients therefore it is necessary to read the complete composition list and consult the doctor in case of any ingredient that induces allergies.
Consult the doctor if you are planning on a pregnancy or breastfeeding.
It is advisable to avoid driving and operating heavy machinery during the course of Phesgo.
Indications of PHESGO Injection
Phesgo indicated for the treatment of patients with HER2-positive breast cancer that is advanced or has spread to other parts of the body. It will also be given before or after the surgery if the cancer has not spread to other parts of the body.
Therapeutic Effects of PHESGO Injection
Phesgo Injection contains Pertuzumab and trastuzumab, which belongs to the class of monoclonal antibodies. It works by selectively binding human epidermal growth factor receptor 2 (HER2) protein and inhibits the excess production. This causes inhibition of the cancer cell growth and, finally, initiation of apoptosis.
Directions for Use
Phesgo is usually given as an intravenous injection once every 3 weeks. This medication may be used in combination with other chemotherapy medications. The dosage and duration of treatment will depend on the individual’s condition and response to the medication and should be determined by the doctor.
Your doctor will decide the dose and frequency of administration based on your health condition.
A trained healthcare doctor will administer Phesgo. So, do not self-administer.
Storage
Phesgo Injection should be stored in refrigerator at 2°C to 8°C. Do not freeze.
If you are traveling, carefully follow all patient instructions for storing your medicine during travel. Avoid extreme heat or cold.
Keep in the original container to protect from light and moisture.
Keep Phesgo Injection out of sight and reach of children.
Common:
- Constipation
- Hair Loss
- Rash
- Sore mouth
- Poor appetite
- Changes in taste
- Sleeping troubles
- Nose Bleeds
- Heartburn
- Nail problems
- Producing more tears
- Feeling dizzy
- Dry and itchy skin
- Ear, nose, or throat infection
Serious:
- Severe or persistent diarrhea
- Low white blood cell count
- Infusion reactions with symptoms that can either be mild or more severe and may include feeling sick (nausea), fever, chills, feeling tired, headache, loss of appetite, joint and muscle pains, and hot flushes.
- Allergic and anaphylactic (more severe allergic) reactions with symptoms that may include swelling of your face and throat, with difficulty in breathing.
- Heart problems (heart failure) with symptoms that can include cough, shortness of breath, and swelling (fluid retention) in your legs or arms.
- Tumour lysis syndrome (a condition which may happen when cancer cells die quickly, causing changes in blood levels of minerals and metabolites shown in a blood test). Symptoms may include kidney problems (weakness, shortness of breath, fatigue and confusion), heart problems (fluttering of the heart at a faster or slower heartbeat), seizures, vomiting or diarrhoea and tingling in the mouth, hands or feet
Tell a doctor or nurse straight away, if you notice any of the side effects above.
Contraindications
Phesgo Injection is contraindicated in patients with a known hypersensitivity to Phesgo or any of the excipients.
Drug Interactions
Drug-Drug Interactions: Phesgo Injection may interact with anti-cancer drugs (anastrozole, carmustine, daunorubicin), monoclonal antibodies (abciximab, adalimumab), antibiotics (bleomycin), local anaesthetics (bupivacaine, butacaine).
Drug-Food Interactions: Avoid alcohol consumption and smoking.
Drug-Disease Interactions: Tell your doctor if you have heart problems like heart failure, irregular heartbeats, and uncontrolled high blood pressure, liver or kidney disease, lung disease problems.
Safety Advices for Phesgo Injection
Consult Your Doctor
It is unknown whether Phesgo Injection interacts with alcohol. It is best to avoid alcohol or limit your alcohol consumption while taking any medication. Consult your doctor.
Unsafe
Phesgo Injection is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before taking Phesgo Injection. You should not become pregnant while you are taking Phesgo Injection for at least one week after your last dose of treatment. Using effective birth control methods while on treatment is suggested.
Unsafe
It is not known whether Phesgo passes into breast milk. Consult your doctor if you are breastfeeding before taking this medication.
Unsafe
Phesgo may cause dizziness, lightheadedness, or fainting in some patients. Therefore, avoid driving or operating machines that require mental concentration until you are not alert.
Consult Your Doctor
Limited data are available on the effect of Phesgo in hepatic-impaired patients. If you have a pre-existing or a history of liver problems, consult your doctor before taking this medicine. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.
Consult Your Doctor
Limited data are available on the effect of Phesgo in kidney-impaired patients. Hence, if you have a pre-existing or a history of kidney disease, inform your doctor. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.
Unsafe
Phesgo is not recommended for use in children as the safety and efficacy are not established.
FAQs
Ans – Phesgo is an intravenous injection used in the treatment of breast cancer.
Ans –Phesgo is consider cancer therapy and different from chemotherapy. Chemotherapy works by killing fast-growing cancer cells, but it also affects normal cells. Phesgo attacks certain proteins in breast cancer cells that cause rapid growth.
Ans –If you have active tuberculosis (TB) infection, Phesgo 600mg/600mg Injection should not be used until the TB infection has been treated and is under control. These drugs can suppress the immune system, worsening TB or other infections.
Ans - Avoid drinking alcohol during the treatment with Phesgo even though no interactions of both are known.
Ans - It is advisable to avoid driving and operating heavy machinery as Phesgo causes dizziness as one of the side effects.
Ans – Phesgo can cause harm to the fetus hence, it is advisable to avoid the pregnancy or consult the doctor for the same.
Ans –Yes, Phesgo 600mg/600mg Injection can be used in older adults. However, older adults may be at elevated risk of side effects such as heart-related complications or infections. Healthcare providers consider adjusting the dose and closely monitoring older patients for potential side effects
- 1. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 1095.
- 2. Pertuzumab [FDA Label]. South San Francisco, CA: Genentech, Inc.; 2012. [Accessed 05 Feb. 2020] (online) Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/125409lbl.pdf
- 3. Sandra M Swain et al; Pertuzumab, Trastuzumab, and docetaxel in HER2-positive metastatic breast cancer; The New England Journal of Medicine; [Published on Feb 2015]; [Accessed on 03/05/203]; https://pubmed.ncbi.nlm.nih.gov/25693012/
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