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Product Description
Plamumab Injection contains Adalimumab which belongs to the group of medicines called Disease-Modifying Anti-Rheumatic Drug (DMARDs) and a monoclonal antibody. It is used to treat rheumatoid arthritis (RA), psoriatic arthritis (PsA), polyarticular juvenile idiopathic arthritis, enthesitis-related arthritis, ankylosing spondylitis, plaque psoriasis (Ps), Hidradenitis suppurativa, Crohn’s disease, ulcerative colitis, and uveitis. Adalimumab works to reduce pain, inflammation, and skin symptoms in chronic autoimmune conditions.
However, the uses of the medicine mentioned are not exhaustive; there may be other reasons or situations in which the medicine might be used.
It is an immunosuppressive medicine, works by blocking a protein called tumor necrosis factor (TNF) that can cause inflammation, pain, or other autoimmune symptoms.
Inform the doctor about all your medical conditions, prescription and non-prescription drugs, vitamin supplements, herbal medications, since Plamumab can interact with them. Plamumab can cause an allergic reaction in some patients therefore it is necessary to read the complete composition list and consult the doctor in case of any ingredient that induces allergies.
Inform the doctor If you have or have ever had Tuberculosis or any active infection or symptoms; lung or breathing problems; Lipid abnormalities, liver problems; ulcers in your stomach or intestines; a nerve-muscle disease such as multiple sclerosis; diabetes; HIV, or a weak immune system; hepatitis B (or if you are a carrier of the virus); cancer; or if you have received or are scheduled to receive any vaccines.
Consult the doctor if you are planning, on a pregnancy or breastfeeding.
It is advisable to avoid driving and operating heavy machinery during the course of Plamumab.
Adalimumab affects your immune system. You may get infections more easily, even serious or fatal infections. Your doctor will need to examine you on a regular basis.
Indications of PLAMUMAB Injection
Plamumab injection is used for the treatment of :
Rheumatoid arthritis
Psoriatic arthritis
Polyarticular juvenile idiopathic arthritis
Enthesitis-related arthritis
Ankylosing spondylitis
Plaque psoriasis
Hidradenitis suppurativa
Crohn’s disease
Ulcerative colitis
Non-infective Uveitis
Therapeutic Effects of PLAMUMAB Injection
It is an immunosuppressive medicine, works by blocking a protein called tumor necrosis factor (TNF) that can cause inflammation, pain, or other autoimmune symptoms. It helps reduce the swelling, pain and redness associated with autoimmune conditions and improves physical function.
Directions for Use
Plamumab is administered as an injection under the skin using an autoinjector or a prefilled syringe, preferably at the same time each day.
The dosage and duration of treatment will depend on the individual’s condition and response to the medication and should be determined by the doctor. Your doctor will decide the dose and frequency of administration based on your health condition.
A trained healthcare doctor/Nurse will administer Plamumab. Carefully follow the instructions advised by your doctor in case of self-administration.
Storage
Plamumab Injection should be stored below 30°C temperature at room temperature. Do not freeze.
Keep in the original container to protect from light and moisture.
Keep Plamumab Injection out of sight and reach of children.
If you are traveling, carefully follow all patient instructions for storing your medicine during travel.
Avoid extreme heat or cold.
Common:
- Headache
- Injection site reactions (pain, redness, swelling)
- Nausea and Vomiting
- Fever
- Allergic reactions include rash and itching, hives
- Cold symptoms such as stuffy nose, sinus pain, sneezing, sore throat
- Upper respiratory infections
Serious:
- Heart problems (Irregular heartbeats, Heart failure such as rapid breathing, pedal edema, tachypnea)
- Severe skin reactions
- GI bleeding
- Severe respiratory problems
- Abnormal blood count values
- Bone problems
- Muscle weakness
- Difficulty in movements like speaking, chewing, swallowing
- Infections
- Nerve disorders, scarring of the lung
- Liver injury
Tell a doctor or nurse straight away, if you notice any of the side effects above.
Contraindications
Plamumab Injection is contraindicated in patients with a known hypersensitivity to Adalimumab or any of the excipients.
Drug Interactions
Plamumab might interact with other medicines used in the management of joint pain such as azathioprine, anakinra and abatacept, etanercept, cancer medicine such as 6-Mercaptopurine, rituximab, autoimmune disorder medicines such as infliximab. Therefore, it is recommended to inform your doctor about all the medications and supplements you take.
Safety Advices for PLAMUMAB Injection
Consult Your Doctor
It is not known whether Plamumab Injection interacts with alcohol. However, it is best to avoid alcohol or limit your alcohol consumption while taking any medication.
Consult Your Doctor
Plamumab Injection is not recommended for use during pregnancy. Hence, if you are pregnant or planning pregnancy, inform your doctor before taking Plamumab Injection. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Consult Your Doctor
It is not known whether Plamumab passes into breast milk. Consult your doctor if you are breastfeeding before taking this medication.
Unsafe
Plamumab may cause room spinning sensation and vision disturbances in some patients. Therefore, avoid driving or operating machines that require mental concentration until you are not alert.Consult Your Doctor
If you have any lung-related symptoms, consult your doctor before taking Plamumab, as this medication should be used with caution in such conditions. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.
Consult Your Doctor
If you have a pre-existing or a history of liver problems, consult your doctor before taking this medicine. Plamumab should be used cautiously in liver disease patients. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.
Consult Your Doctor
If you have a pre-existing or a history of kidney disease, inform your doctor. Plamumab should be used cautiously in patients with mild to moderate kidney disease. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.
Consult Your Doctor
PLAMUMAB should be used with caution in patients with moderate to severe heart failure. Consult your doctor before receiving PLAMUMAB.
FAQs
Ans-Plamumab 40mg Injection (0.8ml Each) is a TNF blocker medicine that can lower the ability of your immune system to fight infections. Inform your doctor if you have been suffering from any infections before taking this medicine.
Ans - Plamumab 40mg Injection (0.8ml Each) is a biological disease-modifying antirheumatic drug (bDMARD) and may be used with other medicines like methotrexate (DMARDs); prednisolone (steroid); naproxen or ibuprofen (anti-inflammatory medicines) and paracetamol (pain killers). However, it cannot be used with other bDMARDs. Your doctor will be able to give you more information on this.
Ans – Yes, Plamumab (Adalimumab) was approved by Food and Drugs Administration FDA.
Ans - Yes. PLAMUMAB 40MG INJECTION can increase the risk of infections. It includes skin infections, flu, gut infections, UTI, reproductive tract infections, respiratory tract infections, oral infections, ear infections, fungal infections, meningitis, tuberculosis, or hepatitis. This is because PLAMUMAB 40MG INJECTION works by suppressing your immune system. Therefore, consult your doctor immediately if you experience any signs of infection.
Ans - It is advisable to avoid driving and operating heavy machinery as PLAMUMAB causes room spinning sensation and vision disturbances in some patients.
Ans- PLAMUMAB 40MG INJECTION should be used with caution in elderly patients. Therefore, consult your doctor before receiving it. Proper dose adjustments and careful monitoring are required in such patients.
- 1. KD. Tripathi. Antirheumatoid and antigout drugs. Immunosuppressant drugs Essentials of Medical Pharmacology. 7th Edition. 2013. Page – 212 & 884.
- 2. Adalimumab. NHS. UK. [Revised in March 2022]. [Accessed on 27th March 2023] https://www.nhs.uk/medicines/adalimumab/side-effects-of-adalimumab/
- 3. AbbVie Biotechnology GmbH. Humira 40 mg solution for injection in pre-filled syringe. Adalimumab. European Medicines Compendium. [Revised in April 2021]. [Accessed on 27th March 2023] https://www.medicines.org.uk/emc/files/pil.2150.pdf
- 4. AbbVie Inc. HUMIRA® (adalimumab) injection, for subcutaneous use. U. S. Food and Drug Administration. [Revised in August 2018]. [Accessed on 27th March 2023] https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/125057s410lbl.pdf
- 5. Humira Package Insert FDA https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/125057s0276lbl.pdf
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