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Product Description
PLEGRIDY contains the active substance Peginterferon Beta-1A. It is used to treat relapsing forms of multiple sclerosis (MS) in adults. Multiple sclerosis is a long term illness that affects the central nervous system (CNS) including the brain and spinal cord, in which the body’s immune system (its natural defense) damages the protective layer (myelin) surrounding the nerves in the brain and spinal cord.
PLEGRIDY helps to suppress the body’s immune system, thereby reducing the number of relapses and slow down the progression of the disease.
Inform the doctor if you have any active infection, low leucocyte count, low immune system, seizure disorders, severe depression, hypertension, diabetes, thyroid, liver or kidney problems,
Inform the doctor about all your medical conditions, prescription and non-prescription drugs, vitamin supplements, and herbal medications, as PLEGRIDY can interact with them. PLEGRIDY can cause an allergic reaction in some patients therefore it is necessary to read the complete composition list and consult the doctor in case of any ingredient that induces allergies.
Consult the doctor if you are planning, on a pregnancy or breastfeeding.
It is advisable to avoid driving and operating heavy machinery during the course of PLEGRIDY
Indications of PLEGRIDY Injection
PLEGRIDY is a prescription medicine used to treat relapsing forms of multiple sclerosis (MS) in adults, including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease.
Therapeutic Effects of PLEGRIDY Injection
PLEGRIDY helps to suppress the body’s immune system from damaging brain and spinal cord, thereby reducing the number of relapses and slowing disease progression. It further reduces the inflammation of the damaged nerves, prevents further damage and stabilizes the immune system.
Directions for Use
PLEGRIDY is typically administered either as an injection under the skin or as an intravenous infusion. Taking these medicines regularly at the same time increases their effectiveness. A dose of this medicine should not be missed as it can affect your recovery. The dosage and duration of treatment will depend on the individual’s condition and response to the medication. Your doctor will decide the dose and frequency of administration based on your health condition.
A trained healthcare doctor will administer PLEGRIDY injection. So, do not self-administer.
Storage
PLEGRIDY Injection should be stored in refrigerator at 2°C to 8°C. Do not freeze.
If you are traveling, carefully follow all patient instructions for storing your medicine during travel. Avoid extreme heat or cold.
Keep the medicine in the original container to protect from light and moisture.
Keep PLEGRIDY Injection out of sight and reach of children.
Common:
- Flu-like symptoms
- Injection site reactions
- Nausea
- Headache
- Fatigue
- Mood changes
- Muscle pain
- Fever
- Feeling weak and tired
- Itchy skin
Serious:
- Allergic reactions
- Liver problems
- Depression
- Seizures
- Blood problems
- Kidney problems
- Cardiovascular issues
Tell a doctor or nurse straight away, if you notice any of the side effects above.
Contraindications
PLEGRIDY Injection is contraindicated in patients with a known hypersensitivity to PLEGRIDY or any of the excipients.
Safety Advices for PLEGRIDY Injection
Consult Your Doctor
It is unknown whether PLEGRIDY interacts with alcohol. However, it is best to avoid alcohol or limit your alcohol consumption while taking any medication.
Consult Your Doctor
If you are pregnant or planning to get pregnant during the treatment, please consult your doctor as there is limited information on the safety of PLEGRIDY 125mcg injection in pregnant women. Your doctor will prescribe any potential risks if the benefits are found to outweigh the risks.
Consult Your Doctor
It is not known whether PLEGRIDY 125mcg injection passes into breast milk. It is, therefore, important to talk to your doctor before using it if you are breastfeeding.
CONSULT YOUR DOCTOR
PLEGRIDY has no or negligible influence on the ability to drive. However, if you experience decreased alertness, feel sleepy and dizzy; do not drive or operate machines if these symptoms occur.
Consult Your Doctor
If you have pre-existing or a history of lung problems, consult your doctor before taking PLEGRIDY. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.
Consult Your Doctor
If you have a pre-existing or a history of liver problems, consult your doctor before taking PLEGRIDY. It should be used cautiously in liver disease patients. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition
Consult Your Doctor
If you have a pre-existing or a history of kidney disease, consult your doctor before taking PLEGRIDY as it should be used cautiously in patients with moderate to severe renal impairment. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.
UNSAFE
PLEGRIDY is not recommended for use in children below 18 years old as the safety and efficacy are not established.
- 1.. National Institute for Health and Excellence, Peginterferon beta-1a for treating relapsing–remitting multiple sclerosis, [Revised on 19th Feb 2020] [Accessed on 16th Sept 2023], https://www.nice.org.uk/guidance/ta624/resources/peginterferon-beta1a-for-treating-relapsingremitting-multiple-sclerosis-pdf-82609017256645
- 2. Biogen Idec Ltd, Electronic Medicines Compendium (EMC), [Revised on 26 Jul 2023] [Accessed on 16th Sept 2023], https://www.medicines.org.uk/emc/product/3409/smpc#gref
- 3. PAUL R. LEE, US Food and Drug Administration[Revised on 29th Jan 2021 ] [Accessed on 16th Sept 2023],https://www.accessdata.fda.gov/drugsatfda_docs/appletter/2021/125499Orig1s021ltr.pdf
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| Plegridy 125mcg | Plegridy 125mcg |
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