TYSABRI contains the active substance Natalizumab. It is used for the treatment of multiple sclerosis (a condition in which the immune system attacks the protective covering of the nerves called myelin, causing disrupted communication between the brain and body) and moderately to severe Crohn’s disease (a chronic bowel disease that affects any part of the gastrointestinal tract, mainly small and large intestine) in patients who are unable to tolerate conventional Crohn’s disease therapy and inhibitors of TNF-α.

It belongs to the group of medicines called integrin receptor antagonists. It works by binding to the chemical substance called α4β7 integrin (present on the surface of the leukocytes that enters the gut), which is responsible for inflammation. This slows progression of disease and reduces the number of attacks in multiple sclerosis.

Inform the doctor if you have or have ever had Tuberculosis or any active infection, bleeding disorders, injury, GI perforation, fistula formation, proteinuria, thromboembolic disorders, diabetes, hypertension or heart problems, dental problems, kidney problems and liver problems (such as hepatic injury).

Inform the doctor about all your medical conditions, prescription and non-prescription drugs, vitamin supplements, herbal medications, since TYSABRI can interact with them. TYSABRI can cause an allergic reaction in some patients therefore it is necessary to read the complete composition list and consult the doctor in case of any ingredient that induces allergies. This medicine may make your skin more sensitive to sun, so it is better to use good sunscreen and protective clothing when outdoors.

Consult the doctor if you are planning, on a pregnancy or breastfeeding. It is advisable to avoid driving and operating heavy machinery during the course of TYSABRI.